Is Depression Related to Inflammation?

Fascinating piece by Therese Borchard. She discusses various triggers, including sugar. You can find the article Could Depression Be an Allergic Reaction? here. And here is an excerpt:

piece by Caroline Williams in The Guardian cites the growing number of studies that suggest depression is, in fact, a result of inflammation. One study published in the Journal of Affective Disorders found that both depression and mania are associated with pro-inflammatory states. A spike in cytokines, proteins that are pumped into our blood stream when our immune system is fighting off a foreign agent, happens when people are depressed. The process looks the same as when a person is fighting an infection of any kind. A study published in Biological Psychiatry reported that brain images of volunteers injected with a typhoid vaccine, which produces robust inflammation, showed changes in the prefrontal regions of the brain that affect motivation and concentration.

Williams builds the case: “There are other clues, too: people with inflammatory diseases such as rheumatoid arthritis tend to suffer more than average with depression; cancer patients given a drug called interferon alpha, which boosts their inflammatory response to help fight the cancer, often become depressed as a side-effect.”